Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres

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چکیده

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Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres

SLX4, a scaffold for structure-specific DNA repair nucleases, is important for several types of DNA repair. Many repair proteins bind to sites of DNA damage, resulting in subnuclear "foci," but SLX4 forms foci in human cells even without DNA damage. Using several approaches, we show that most, but not all, SLX4 foci localize to telomeres in a range of human cell lines irrespective of the mechan...

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ژورنال

عنوان ژورنال: Cell Reports

سال: 2013

ISSN: 2211-1247

DOI: 10.1016/j.celrep.2013.07.033